Background: The present study aimed to compare the intravenous bolus effect of oxycodone and fentanyl\non hemodynamic response after endotracheal intubation and postoperative pain in patients undergoing\nclosed reduction of nasal bone fracture.\nMethods: In this prospective randomized double-blinded study, 64 patients undergoing closed reduction of\nnasal bone fracture were randomized into one of two groups: the fentanyl group (Group F) or the oxycodone\ngroup (Group O). Each drug (fentanyl 2 mcg/kg in Group F and oxycodone 0.2 mg/kg in Group O) was administered\nprior to the induction of general anesthesia. Hemodynamic changes after endotracheal intubation and postoperative\npain were then measured in both groups.\nResults: There was no significant difference in the change in mean arterial pressure and heart rate between\npre-induction and post-intubation in both Groups F and O (P > 0.05). Postoperative pain in Group O was\nmilder than that in Group F (P < 0.001); however, time to awakening from the end of operation was shorter\nin Group F (P = 0.012).\nConclusion: In patients undergoing closed reduction of nasal bone fracture, oxycodone attenuates hemodynamic\nresponse to endotracheal intubation similar to fentanyl. However, oxycodone is more effective than fentanyl\nin improving postoperative pain.
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